Explore Info on Inflammation – Medical Marijuana Research Overview
Inflammation – Medical Marijuana Research Overview Severe inflammation is as a result of the immune system behaving abnormally. This triggers organ, tissue or joint damage. Research conducted has revealed that the use of cannabis can reduce severe inflammation and also can assist patients to control the pain that is linked to the inflammation.
What really is inflammation?
Actually, we can refer inflammation as the response by the body’s immune system due to a virus, bacteria or an injury. But there are moments when the inflammation occurs yet it is not triggered by them. When an inflammation occurs in the right manner, it eliminates the damaging or infectious stimuli in order for the body to start a curing process. But when the inflammation is triggered incorrectly, because of autoimmune ailments, the immune system responds by assuming that the tissues have been infected, when the reality is that they are in a perfect state. This is where you find the body destroying its very own tissues.
Severe inflammation which appears and disappears because of diseases and injuries is a sign of a good immune system. On contrary, when chronic inflammation occurs, it is a sign of a weak immune system, because it is not able to respond to the inflammation.
An example of an inflammation associated disease is rheumatoid arthritis. This is a severe inflammatory ailment that brings about the destruction of the joints, making them to become deformed and unable to function properly. Another disease is the psoriatic arthritis that triggers pain, swelling, and stiffness in the joints. It also causes the skin to have red spots. Other ailment are the inflammatory bowel diseases and the Crohn’s , whereby inflammation occurs at the digestive tract. As for the atherosclerosis, it is the arterial walls that get inflamed causing a blockage of blood flow, which can lead to stroke, cancer or heart attack.
To treat these diseases of inflammation, there is need to use anti-inflammatory drugs, and the modification or abstinence of certain activities which can cause the inflamed area to get stresses. On particular occasions, an operation is necessary.
Results: marijuana effects on inflammation
Through the cannabinoids that are: the cannabidiol (CBD) and the tetrahydrocannabidiol (THC), medical cannabis is proved to decrease the severe inflammation and control the pain linked to the inflammatory ailments.
CBD and THC have proved to decrease a number of inflammatory conditions. For instance, severe inflammatory ailment, stroke and heart attack causes, and the development of atherosclerosis can be limited by THC. As for CBD, it has been proved to have the power of restraining the spread of joint inflammation and reducing it too. Also, CBD has effectively reduced edema as for the Crohn’s disease, marijuana has the ability of reducing the inflammation at the digestive track, to the extent of healing it fully. Other researches indicate that the cannabinoids that are found in cannabis are advantageous in inhibiting some cancer types which are caused by chronic inflammation.
Whereas CBD and THC show positive results as anti-inflammatory agents, each of the two cannabinoids functions in a different manner. The two can cannabinoids lower the manufacture and discharge of pro-inflammatory cytokines. Also, they limit the activation of LPS-stimulated STAT1 transcription factor, which is an important factor in the pro-inflammatory progression. NF-kappaB pathway activity can be reduced by CBD. This pathway is a basic one when controlling the pro-inflammatory genes, and also in controlling the STAT3 transcription factor activation, which stimulates anti-inflammatory activities. Apart from that, CBD helps inn anti-inflammation labors through restraining of fatty acid amidohydrolase event that ends in an increase of anandamine and anti-inflammatory endocannabinoid.
Inflammatory pain is a familiar sign of quite a number of severe inflammatory ailments like cancer and sickle cell. The use of marijuana has proved to be beneficial in controlling pain. Actually, the cannabinoids found in marijuana, work upon cannabinoid receptors CB1 and CB2. These receptors are the ones which mediate inflammation linked pain. Research studies have proved that CBD perfectly decreases neuropathic pain through the decrease of the inflammation triggering sciatic nerve development. Inflammation – Medical Marijuana Research Overview
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